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. 2023 May 18;11:1161778. doi: 10.3389/fcell.2023.1161778

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Copyright © 2023 Chen, Li, Mak, Wang, Ren, Wang, Kuo, Wu, Li, Hao, Zhang and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characteristics in clinicopathology and gene mutation in GC. (A, B) The univariate and multivariate cox regression analysis in Risk-score subgroups. (C, D) Significantly mutated genes in the mutated GC samples of the high and the low risk groups, respectively. Mutated genes (rows, top 20) are ordered by mutation rate; samples (columns) are arranged to emphasize mutual exclusivity among mutations. The right shows mutation percentage, and the top shows the overall number of mutations. The color-coding indicates the mutation type. (E) The TMB of two different risk subgroups. (F) Relationships between Risk-score and TMB. (G) The prognosis of GC in different Risk-score and TMB subgroup. (H) The prognosis of GC in different Risk-score and TMB.