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. 2023 May 18;10:1094189. doi: 10.3389/fnut.2023.1094189

Table 2.

Univariate and multivariate analyzes of biomarkers for immunotherapy response.

Variables Category Univariate analysis Multivariate analysis
OR OR (95% CI) p value OR OR (95% CI) p value
Sex Male 1.416 0.488 4.111 0.522
Age >60 years 0.471 0.144 1.54 0.213
Site Right 2.523 0.877 7.257 0.086
Lynch syndrome Yes 1.596 0.548 4.65 0.392
Liver metastasis Yes 0.55 0.187 1.619 0.278
Lung metastasis Yes 1.214 0.23 6.421 0.819
Immunotherapy type Anti-PD1 + anti-CALT4 0.481 0.074 3.124 0.443
Chemotherapy Yes 2.526 0.652 9.791 0.18
Anti-angiogenesis Yes 1.848 0.367 9.308 0.457
Line ≥2 0.55 0.187 1.619 0.278
CRP High 0.481 0.097 2.4 0.372
CHO High 0.407 0.138 1.194 0.102
HDLC High 4.017 1.270 12.708 0.018 4.709 1.415 15.666 0.012
ALT High 0.322 0.066 1.561 0.159
AST High 0.336 0.113 1.003 0.051
PNI High 5.1 1.07 24.315 0.041 0.162 0.032 0.815 0.027
LCR High 1.109 0.387 3.176 0.847
SII High 0.654 0.11 3.891 0.641