Table 3.

Univariate and multivariate analyzes of biomarkers for OS.

Variables	Category	Univariate analysis				Multivariate analysis
		HR	95% CI	p value		HR	95% CI		p value
Sex	Female	2.058	0.72	5.882	0.178
Age	<60 years	1.618	0.507	5.165	0.417
site	Left	0.388	0.126	1.193	0.098
Lynch syndrome	No	0.931	0.322	2.691	0.895
Liver metastasis	No	0.312	0.108	0.902	0.031	0.931	0.238	3.645	0.918
Lung metastasis	No	0.488	0.136	1.752	0.272
Immunotherapy type	No	0.471	0.105	2.109	0.325
Chemotherapy	Anti-PD1	1.206	0.377	3.861	0.752
Anti-angiogenesis	No	0.757	0.211	2.721	0.67
Line	1	0.458	0.16	1.312	0.146
CRP	Low	0.033	0	7.475	0.217
CHO	Low	0.239	0.08	0.713	0.01	0.173	0.049	0.613	0.007
HDLC	Low	1.792	0.6	5.353	0.296
ALT	Low	1.814	0.406	8.117	0.436
AST	Low	0.200	0.067	0.596	0.004	0.182	0.039	0.854	0.031
PNI	Low	0.158	0.021	1.207	0.075
LCR	Low	0.298	0.083	1.071	0.064
SII	Low	0.247	0.069	0.89	0.032	0.182	0.039	0.854	0.031