TABLE 1.
Univariable analysis of DILI related variables in the training group a .
| Variable | Total | Non-DILI | DILI | P b |
|---|---|---|---|---|
| N = 1,121 | N = 1,080 | N = 41 | ||
| Gender, n (%) | 0.118 | |||
| Female | 417 (37) | 407 (38) | 10 (24) | |
| Male | 704 (63) | 673 (62) | 31 (76) | |
| Age | 50 (29, 68) | 49 (28.75, 68) | 62 (52, 76) | <0.001 |
| Alcohol consumption, n (%) | <0.001 | |||
| No | 961 (86) | 936 (87) | 25 (61) | |
| Yes | 160 (14) | 144 (13) | 16 (39) | |
| Uric acid (μmol/L) | 287 (222, 366) | 290 (223, 369) | 237 (159, 323) | <0.001 |
| Creatinine (μmol/L) | 61 (51, 71) | 61 (51, 71) | 68 (54, 73) | 0.073 |
| Total bilirubin (μmol/L) | 9.1 (6.9, 12.4) | 9 (6.9, 12.1) | 17.5 (10.2, 20.8) | <0.001 |
| Direct bilirubin (μmol/L) | 3.4 (2.5, 4.7) | 3.3 (2.5, 4.6) | 6.2 (4.1, 9.8) | <0.001 |
| Indirect bilirubin (μmol/L) | 5.6 (4.2, 7.9) | 5.5 (4.2, 7.8) | 9 (6.1, 11.9) | <0.001 |
| Total bile acid (μmol/L) | 3.3 (2, 5.8) | 3.3 (2, 5.8) | 3.3 (2.1, 6.1) | 0.588 |
| Total Protein (g/L) | 68.73 ± 7.92 | 68.94 ± 7.8 | 63.35 ± 9.28 | <0.001 |
| Albumin (g/L) | 39 (34.2, 44) | 39.2 (34.48, 44.1) | 35 (31.7, 39.3) | <0.001 |
| Globulin (g/L) | 29.2 (25.9, 32.7) | 29.3 (26, 32.7) | 27.8 (23.5, 31.9) | 0.03 |
| Alanine aminotransferase (U/L) | 15 (11, 23) | 15 (11, 23) | 18 (13, 30) | 0.029 |
| Aspartate aminotransferase (U/L) | 20 (17, 26) | 20 (16, 26) | 25 (19, 31) | 0.003 |
| Alkaline phosphatase (U/L) | 77 (62, 96) | 77 (62.75, 96) | 67 (60, 88) | 0.257 |
| White blood cell (x10^9/L) | 6.29 (5.14, 7.65) | 6.27 (5.11, 7.62) | 7.37 (5.94, 9.7) | 0.002 |
| Neutrophil count (x10^9/L) | 4.09 (3.14, 5.37) | 4.05 (3.11, 5.32) | 4.66 (4.15, 6.95) | <0.001 |
| Lymphocyte count (x10^9/L) | 1.43 (1.08, 1.82) | 1.44 (1.09, 1.82) | 1.18 (0.85, 1.6) | 0.009 |
| Monocyte counts (x10^9/L) | 0.47 (0.36, 0.63) | 0.47 (0.35, 0.62) | 0.57 (0.45, 0.73) | 0.001 |
| Eosinophil count (x10^9/L) | 0.12 (0.06, 0.19) | 0.12 (0.06, 0.19) | 0.09 (0.04, 0.17) | 0.077 |
| Basophil count (x10^9/L) | 0.02 (0.01, 0.03) | 0.02 (0.01, 0.03) | 0.02 (0.01, 0.03) | 0.789 |
| Hemoglobin (g/L) | 129 (114, 142) | 129 (115, 142) | 120 (101, 135) | 0.015 |
| Red blood cell (x10^12/L) | 4.39 (3.94, 4.86) | 4.4 (3.97, 4.86) | 3.89 (3.52, 4.58) | <0.001 |
| Mean corpuscular hemoglobin (pg) | 29.5 (28.3, 30.7) | 29.5 (28.3, 30.7) | 29.9 (28.7, 31.6) | 0.101 |
| Mean corpuscular hemoglobin concentration (g/L) | 331 (323, 339) | 331 (323, 338) | 333 (324, 339) | 0.46 |
a
Continual variables were displayed as Median (IQR), categorical variables were displayed as number (percentage).
b
Categorical variables were compared by Pearson’s Chi-squared test, continual variables were analyzed by Wilcoxon rank sum test.