Table 5.
Comparison of the current study and previously published literature on surgical treatment of spinal metastasis of DTC.
| Article | No. of cases | Pathologies | Average follow-up | Surgical strategies | Tumor-related outcomes | Favorable prognostic factors |
|---|---|---|---|---|---|---|
| This study | 35 | DTC | 45.7 months | TES: 4 cases, debulking surgery: 31 cases | Median OS: 60 months | Postoperative Frankel grade |
| Yin 2021 (18) | 50 | DTC | 2.5 years | Surgery: 16 cases, non-surgery: 34 cases | 5-year survival rates: 44.7% for surgical group, 11.1% for non-surgical group | Surgery, local disease control |
| Liu 2020 (19) | 11 | DTC | 21.8 months | PVP, partial tumor resection | Average OS: 21.8 months | Non-visceral metastasis, open surgery |
| Zhang 2019 (20) | 52 | All subtypes | 47.1 months | En-bloc resection: 8 cases, curettage: 44 cases | Average OS: 50.2 months | ≤50 years old, single segment involved, follicular thyroid cancer |
| Sellin 2015 (21) | 43 | All subtypes | 39.4 months (median) | Intralesional resection | Median OS: 15.4 months | Preoperative embolization, neurological intact, without progressive systemic disease and complications |
| Jiang 2014 (22) | 21 | DTC | 42.7 months | TES: 3 cases, palliative curettage: 18 cases | No recurrence for TES, 50% for palliative curettage | No factors verified |
| Zhang 2013 (23) | 22 | DTC | 30 months | Total resection: 19 cases, partial resection: 3 cases | No evidence of disease: 86.4% | No mentioned |
| Matsumoto 2013 (24) | 8 | DTC | 6.4 years | TES | No evidence of disease: 62.5% | Not mentioned |
| Quan 2012 (25) | 8 | All subtypes | Not calculated | Surgery: 7 cases, non-surgery: 1 case | Mean survival: 39 months | Not mentioned |
| Demura 2011 (26) | 24 | All subtypes | 55 months | TES: 10 cases, debulking surgery: 14 cases | 5-year survival rate: 74% | TES |
DTC stands for differentiated thyroid cancer; TES, total en-bloc spondylectomy; PVP, percutaneous vertebroplasty; OS, overall survival.