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. 2023 May 18;14:1166128. doi: 10.3389/fimmu.2023.1166128

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Copyright © 2023 Zhang, Lei and Tan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Therapeutic implication of Tex heterogeneity. The quantity of the Tex progenitor and the Tex intermediate subsets in cancer patient could potentially be used as predictors for the inhibitory receptor blockade outcomes. For therapeutic purpose, the Tex progenitors from lymphoid tissues might be expanded via various strategies, followed by manipulating the differentiation basis to cytotoxic Tex intermediate subsets. Finally, the Tex effector function might be further enhanced by combination therapy. TFs, transcription factors; IR blockade, inhibitory receptor blockade.