Table 5.
Age-Stratified Association Between CTSZ Methylation and BC.
| CpG Sites | BC Cases Median (IQR) |
Controls Median (IQR) |
OR (95%CI)
c
per-10% Methylation |
P-value c |
|---|---|---|---|---|
| ≤50 years old (279BC cases vs 392 controls) | ||||
| CTSZ_CpG_1 | 0.26 (0.19-0.33) | 0.31 (0.24-0.37) | 1.47 (1.19-1.82) | <0.001* |
| CTSZ_CpG_5 | 0.15 (0.11-0.19) | 0.18 (0.13-0.21) | 1.47 (1.12-1.92) | 0.006* |
| CTSZ_CpG_6 | 0.26 (0.20-0.33) | 0.29 (0.23-0.34) | 1.19 (1.01-1.41) | 0.038* |
| CTSZ_CpG_7.8 | 0.16 (0.13-0.20) | 0.17 (0.14-0.21) | 1.39 (1.06-1.85) | 0.013* |
| >50 years old (289 BC cases vs 243 controls) | ||||
| CTSZ_CpG_1 | 0.26 (0.20-0.35) | 0.28 (0.19-0.35) | 1.10 (0.86-1.39) | 0.456 |
| CTSZ_CpG_5 | 0.14 (0.10-0.19) | 0.15 (0.11-0.20) | 1.38 (0.98-1.96) | 0.063 |
| CTSZ_CpG_6 | 0.27 (0.22-0.36) | 0.28 (0.22-0.36) | 1.03 (0.78-1.29) | 0.842 |
| CTSZ_CpG_7.8 | 0.17 (0.14-0.22) | 0.18 (0.14-0.23) | 1.28 (0.88-1.55) | 0.186 |
c
Logistic regression, adjusted for experimental batches.
* Statistically significant.