Table 7.
Inter-quartile analysis for CTSZ methylation level between BC cases and controls at early stage.
| CpG sites | Quartiles (methylation range) |
BC cases N (%) | controls N (%) | Total | OR (95%CI) | P-value | Ptrend |
|---|---|---|---|---|---|---|---|
| CTSZ_CpG_1 | Q4 (> 0.36) | 63 (18.8) | 152 (23.9) | 215 | 1 | – | <0.001* |
| Q3 (≤ 0.36) | 66 (19.7) | 175 (26.6) | 241 | 0.913 (0.604-1.380) | 0.667 | ||
| Q2 (≤ 0.29) | 105 (31.3) | 165 (25.9) | 270 | 1.503 (1.022-2.211) | 0.038* | ||
| Q1 (≤ 0.21) | 101 (30.2) | 143 (22.5) | 244 | 1.526 (1.027-2.265) | 0.036* | ||
| CTSZ_CpG_3 | Q4 (> 0.12) | 73 (21.8) | 137 (21.6) | 210 | 1 | – | 0.010* |
| Q3 (≤ 0.12) | 64 (19.1) | 182 (28.7) | 246 | 0.699 (0.461-1.058) | 0.090 | ||
| Q2 (≤ 0.09) | 75 (22.4) | 150 (23.6) | 225 | 0.968 (0.643-1.455) | 0.874 | ||
| Q1 (≤ 0.07) | 123 (36.7) | 166 (26.1) | 289 | 1.272 (0.875-1.849) | 0.208 | ||
| CTSZ_CpG_4 | Q4 (> 0.19) | 88 (26.3) | 144 (22.7) | 232 | 1 | – | 0.402 |
| Q3 (≤ 0.19) | 80 (23.9) | 163 (25.7) | 243 | 0.841 (0.574-1.232) | 0.375 | ||
| Q2 (≤ 0.14) | 82 (24.5) | 161 (25.4) | 243 | 0.795 (0.543-1.163) | 0.237 | ||
| Q1 (≤ 0.09) | 85 (25.3) | 167 (26.2) | 252 | 0.821 (0.562-1.199) | 0.308 | ||
| CTSZ_CpG_5 | Q4 (> 0.20) | 59 (17.6) | 175 (27.6) | 234 | 1 | – | <0.001* |
| Q3 (≤ 0.20) | 74 (22.1) | 152 (23.9) | 226 | 1.449 (0.963-2.179) | 0.075 | ||
| Q2 (≤ 0.16) | 93 (27.7) | 155 (24.4) | 248 | 1.687 (1.137-2.504) | 0.009* | ||
| Q1 (≤ 0.12) | 109 (32.6) | 153 (24.1) | 262 | 1.815 (1.217-2.707) | 0.003* | ||
| CTSZ_CpG_6 | Q4 (> 0.35) | 85 (22.9) | 146 (22.8) | 231 | 1 | – | 0.075 |
| Q3 (≤ 0.35) | 61 (26.8) | 170 (19.4) | 231 | 0.685 (0.457-1.027) | 0.067 | ||
| Q2 (≤ 0.28) | 79 (27.1) | 172 (25.6) | 251 | 0.859 (0.584-1.263) | 0.439 | ||
| Q1 (≤ 0.22) | 110 (23.2) | 147 (32.2) | 257 | 1.315 (0.909-1.901) | 0.146 | ||
| CTSZ_CpG_7.8 | Q4 (> 0.21) | 75 (25.4) | 149 (23.5) | 224 | 1 | – | 0.045* |
| Q3 (≤ 0.21) | 69 (20.6) | 164 (25.8) | 233 | 0.980 (0.650-1.478) | 0.924 | ||
| Q2 (≤ 0.17) | 68 (20.3) | 141 (22.2) | 209 | 1.174 (0.769-1.793) | 0.458 | ||
| Q1 (≤ 0.14) | 123 (36.7) | 181 (28.5) | 304 | 1.579 (1.078-2.312) | 0.019* | ||
| CTSZ_CpG_9.10 | Q4 (> 0.40) | 78 (23.3) | 159 (25.0) | 237 | 1 | – | 0.131 |
| Q3 (≤ 0.40) | 67 (20.0) | 152 (23.9) | 219 | 0.946 (0.634-1.410) | 0.784 | ||
| Q2 (≤ 0.34) | 84 (25.1) | 150 (23.6) | 234 | 1.156 (0.787-1.697) | 0.459 | ||
| Q1 (≤ 0.28) | 106 (31.6) | 174 (27.4) | 280 | 1.165 (0.804-1.688) | 0.419 |
*Statistically significant.