Table IV.
Odds ratios (ORs) for premature ovarian insufficiency (POI) by the number of chromosomal abnormality and congenital malformation diagnoses.
| Number of genetic or congenital malformation diagnoses | POI cases |
Controls |
OR | 95% CI of OR | ||
|---|---|---|---|---|---|---|
| n | % | n | % | |||
| Turner syndrome included | ||||||
|
| ||||||
| 0 | 4510 | 90.40 | 18 817 | 96.54 | 1.0 | Ref. |
| 1 | 338 | 6.77 | 630 | 3.23 | 2.2 | 2.0–2.6 |
| 2 | 96 | 1.92 | 36 | 0.18 | 11.1 | 7.6–16.3 |
| ≥3 | 45 | 0.90 | 9 | 0.05 | 20.9 | 10.2–42.7 |
|
| ||||||
| Turner syndrome excluded | ||||||
|
| ||||||
| 0 | 4508 | 92.95 | 18 309 | 96.56 | 1.0 | Ref. |
| 1 | 276 | 5.69 | 609 | 3.21 | 1.8 | 1.6–2.1 |
| 2 | 43 | 0.89 | 35 | 0.18 | 5.0 | 3.2–7.8 |
| ≥3 | 23 | 0.47 | 9 | 0.05 | 10.4 | 4.8–22.4 |