Table 1.
Demographics and Medical Comorbidities of Candida BSI Case Patients and Frequency-Matched Control Patients
| Characteristic | Candida Cases N = 626 n (%) | Matched Controls N = 6269 n (%) |
|---|---|---|
| Age, median (IQR) years | 58 (46–66) | 61 (52–70) |
| Sex | ||
| Female | 268 (42.8) | 2952 (47.1) |
| Race | ||
| White | 437 (69.8) | 4603 (73.4) |
| Black | 146 (23.3) | 1343 (21.4) |
| Other | 43 (6.9) | 323 (5.2) |
| Hierarchical categoriesa of medical conditions (hierarchical rank) | ||
| Leukemia, myelodysplastic syndrome, bone marrow transplant (1) | 143 (22.8) | 1416 (22.6) |
| Central venous catheter, dialysis catheter (2) | 338 (54.0) | 3379 (53.9) |
| Solid organ transplant (3) | 3 (0.5) | 30 (0.5) |
| Lymphoma, metastatic cancer (4) | 40 (6.4) | 408 (6.5) |
| Fistula, pancreatitis, abdominal surgery (5) | 35 (5.6) | 368 (5.8) |
| Bacteremia (6) | 24 (3.8) | 233 (3.7) |
| Cardiac surgery (7) | 8 (1.3) | 80 (1.3) |
| Chronic liver disease (8) | 18 (2.9) | 189 (3.0) |
| Drug abuse (9) | 6 (1.0) | 60 (1.0) |
| Acute renal failure (10) | 11 (1.7) | 107 (1.7) |
The 1:10 frequency-match distribution of the hierarchical categories is not exact due to patients excluded due death occurring within 24 hours of admission.
Abbreviations: BSI, bloodstream infection; IQR, interquartile range.
Candida BSI cases and frequency-matched controls were placed into the first risk factor category for which they had a qualifying diagnosis. They remained in that category without regards to subsequent risk factors. Finally, for the control candidates, if they did not match with a Candida BSI case patient, they could not be bumped to a risk factor category lower in the hierarchy.