Table 2.

Synergy and antagonism screen with masarimycin

Antibiotic	MICapp antibiotic* (µM)	FIC antibiotic	MICapp masarimycin† (µM)	FIC masarimycin	FICindex
Ampicillin	0.010	1	2	0.25	1.25
Bacitracin	1.66	0.5	15.6	2	2.5
Cefoxitin	0.69	0.4	4	0.5	0.9
Cefuroxime	0.012	1.59	2	0.25	1.75
Fosfomycin	85.87	0.5	32	4	4.5
Kanamycin	43	0.5	1.66	0.21	0.71
Levofloxacin	1.08	0.5	32	4	4.5
Optochin	7.96	0.5	8	1	1.5
Rifampicin	0.0023	0.124	3.33	0.416	0.54
Tetracycline	0.048	0.75	2	0.25	1
Vancomycin	0.003	1	4	0.5	1.5

*MIC for antibiotics alone. ampicillin: 0.010 µM; bacitracin: 3.325 µM; cefoxitin: 1.72 µM; cefuroxime: 0.008 µM; fosfomycin: 171.5 µM; kanamycin: 86 µM; levofloxacin: 2.16 µM; optochin: 15.85 µM; rifampicin: 0.018 µM; tetracycline: 0.065 µM; vancomycin: 0.003 µM.

†MIC masarimycin 8 µM.