Figure 5.

Glucose tolerance is enhanced only under low-fat diet (LFD) conditions in ovariectomized (OVX) skeletal-muscle–specific aromatase overexpression (SkM-Arom↑) mice. After approximately 12 weeks of dietary and doxycycline treatment (LFD or high-fat diet [HFD]), OVX female mice were metabolically assessed by examining an A, glucose tolerance test (GTT); B, insulin response to the GTT; a C, insulin tolerance test (ITT); and D, Δ plasma free fatty acid (FFA) in response to insulin administration (n = 13-20). Bar graphs not sharing a common letter are statistically significantly different from one another (P < .05). %, main effect of diet; &, main effect of genotype; #, main effect for interaction; ME, main effect.