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Representative genes associated with change in WMH over time (P < 0.05). Patients are divided by quartiles of change in WMH, with quartile 1 (dark blue) being slow progression and quartile 4 (orange) fast progression. Genes shown include: (A) ADAM8, (B) CFD, (C) EPHB4, (D) FPR2; FAK, (E) MSRB1, (F) PTK2 (protein tyrosine kinase), (G) SIGLEC1 and (H) WLS (Wnt ligand secretion mediator).
