Table 2.
Pathways from the 148 genes associated with change in WMH volume over time
| Genes | P-value | |
|---|---|---|
| Canonical pathways | ||
| Rho signalling | ACTA1, ANLN, CDH7, GNB2, MYL12B, PIP4K2C, PTK2, RHOB | 0.0010 |
| Integrin signalling | ACTA1, CAPN5, MYL12B, PTK2, RHOB, TSPAN2 | 0.0020 |
| Ephrin B signalling | EPHB4, GNB2, PTK2, SDCBP | 0.0100 |
| CXCR4 signalling | GNB2, MYL12B, PTK2, RHOB | 0.0195 |
| Interferon signalling | IFNGR2, MX1 | 0.0204 |
| FAK signalling | ACTA1, CAPN5, PTK2 | 0.0263 |
| Thrombin signalling | GNB2, MYL12B, PTK2, RHOB | 0.0398 |
| Functional pathways | ||
| Degranulation of phagocytes | ADAM8, CD9, CFD, CYSTM1, DUSP1, DYNC1LI1, FPR2, GOLGA7, JUNB, PGM2, QPCT, S100P, SDCBP | 0.0002 |
| Chemotaxis of macrophages | FPR2, MTUS1, PTK2, RHOB | 0.0072 |
| Cell movement of phagocytes | ADAM8, CD9, CFD, DUSP1, FPR2, MTUS1, PROK2, PTK2, QPCT, RHOB, SCN9A, WLS | 0.0101 |
| Infiltration by neutrophils | ADAM8, CFD, DUSP1, FPR2, WLS | 0.0177 |
| Acute inflammation of tissue | FPR2, TRADD | 0.0239 |
| Complement activation | CFD | 0.0303 |