Figure 2.

Accuracy of plasma p-tau₁₈₁ in discriminating brain donors with and without autopsy-confirmed Alzheimer’s disease. NIA–Reagan Institute criteria were used for the neuropathological diagnosis of Alzheimer’s disease. Analyses were done in the entire sample and stratified by CDR score ≥1 and CDR score <1. AUC statistic was calculated based on p-tau₁₈₁ alone (Model 1) and using predicted probabilities from multivariable binary logistic regression that included age at death, years between last blood draw and death, sex (1 = female, 0 = male) and APOE ε4 status (1 = ε4 carrier, 0 = non-carrier; Model 2). For the entire sample, a third model was done that included Model 2 covariates in addition to inclusion of global CDR score at the time of blood draw (Model 3). This model was not done in those stratified by CDR score. p-tau = phosphorylated-tau.