Table 4.

Accuracy of plasma p-tau₁₈₁ in discriminating donors with and without autopsy-confirmed Alzheimer’s disease stratified by blood draw greater than and less than 5 years before death

	AUC	95% CI	P-value
Blood draw less than 5 years before death (n = 45)
Autopsy-confirmed Alzheimer’s disease
Model 1	0.83	0.71–0.95	<0.01
Model 2	0.85	0.74–0.97	<0.01
Model 3	0.91	0.83–1.00	<0.01
Blood draw greater than 5 years before death, n = 58
Autopsy-confirmed Alzheimer’s disease
Model 1	0.65	0.51–0.80	0.049
Model 2	0.71	0.58–0.85	<0.01
Model 3	0.77	0.65–0.90	<0.01

Model 1 examined plasma p-tau₁₈₁ alone. Model 2 was based on predicted probabilities from binary logistic regression that included plasma p-tau₁₈₁, age at death, years between last blood draw and death, sex and APOE ε4 status. Model 3 was also based on predicted probabilities from binary logistic regression that included Model 2 covariates in addition to global CDR score at time of blood draw.