Fig. 7.

NRN1 engages proteins within modules linked to cognitive resilience in human brain.A, to directly compare NRN1-induced changes in the context of human biology, a Fisher’s exact test was used to calculate significant enrichment of proteins from the entire rat proteome (top row), significantly increased with NRN1 (middle row) and significantly decreased with NRN1 (bottom row) treatment across the 39 human consensus modules (0.05 > p > 0.01 = ∗, 0.01 > p > 0.005 = ∗∗, p < 0.005 = ∗∗∗). B, proteins significantly impacted by NRN1 treatment that overlap with human modules were visualized as a heatmap. Rat protein abundance was compared using Bicor across NRN1-treated and vehicle-treated groups. NRN1, neuritin.