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. 2023 Jun 1;13(24):16413–16452. doi: 10.1039/d3ra01888a

Summary of the features of the AP isoenzymes.

Organ/tissue Isoenzymes Functions of the isoenzyme ALP activity (IU g−1 tissue) References
Intestine IAP • Lipids absorption 38 ± 14 50, 66, 86–88
• Removal of bacterial lipopolysaccharides and free nucleotides
• Control of the bacterial transmucosal passage
• Reduced gut inflammatory response
• Dephosphorylation of tricellular adenosine triphosphate (ATP) to adenosine
Colon IAP, colonic TNAP • Reduction of inflammation and oxidative stress 2.3 ± 0.8 89 and 90
Testis GCAP • Sperm glycolytic reactions and fructose production 0.5 ± 0.1 91
Placenta PLAP • Tumor marker 69 ± 44 30, 91 and 92
• Removal of bacterial endotoxins from the body
Bone TNAP • Bone development and mineralization 91
• Sign of osteoblastic activity
Liver TNAP • Breakdown of phosphorylcholine 2.6 ± 1.4 93
Kidney TNAP • Dephosphorylation and detoxification of ATP 2.1 ± 0.7 94
Lung TNAP • Repair of damaged tissue and the clearance of mucus 2.1 ± 0.5 95
• Formation of new blood vessels and the repair of damaged tissue
Vagina, endometrium TNAP • Maintenance of acidic pH 96 and 97
• Maintenance of vaginal flora
• Wound healing
• Endometrial development
• Menstrual cycle
• Pregnancy
Eyes TNAP • Ocular development 98 and 99
• Maintenance of the retinal pigment epithelium
• Removal of toxic waste products
• Regulation of cell growth and differentiation
• Age-related macular degeneration
• Retinitis pigmentosa