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. 2023 Jun 1;13(24):16413–16452. doi: 10.1039/d3ra01888a

Chemical structures of 3-(2-(benzylideneamino)thiazol-4-yl)-2H-chromen-2-one derivatives and IC50 values against AP inhibitors.

Compound no. Chemical structures & IUPAC names IC50 (μM) References
h-TNAP h-IAP h-e5′NT r-e5′NT
35 graphic file with name d3ra01888a-u32.jpg 0.51 0.39 0.25 139
36 graphic file with name d3ra01888a-u33.jpg 0.33 0.28 139
37 graphic file with name d3ra01888a-u34.jpg 0.22 5.15 139
38 graphic file with name d3ra01888a-u35.jpg 0.21 2.23 139
39 graphic file with name d3ra01888a-u36.jpg 0.52 0.05 10.2 139
Standards graphic file with name d3ra01888a-u37.jpg 19.2 139
graphic file with name d3ra01888a-u38.jpg 80.2 139
graphic file with name d3ra01888a-u39.jpg 42.1 77.3 139