TABLE 3.
T/NK-Cell Proliferations in a Setting of CLL/SLL and Miscellaneous Workshop Cases
| Case No. | Age, y/Sex | Panel diagnosis | Interesting features |
|---|---|---|---|
| T/NK-cell proliferations associated with CLL/SLL | |||
| 47 | 57/M | Atypical T/NK-cell proliferation in a setting of CLL/SLL | Patient with refractory CLL/SLL presenting with clinical features concerning for hemophagocytic syndrome. Bone marrow demonstrated CLL/SLL and large highly atypical lymphoid cells, most likely NK cells, which persisted after therapy over a period of several months. |
| 223 | 75/M | ALK-negative ALCL and residual CLL/SLL | Unusual case of ALK–, ALCL arising in a setting of CLL/SLL. Co-occurrence of T-cell lymphomas, and CLL/SLL has been rarely reported. |
| Miscellaneous cases | |||
| 41 | 45/F | CLL with focal EBV reactivation | Focal areas of necrosis and EBV positivity in a patient with CLL/SLL, most likely related to immunosuppression. |
| 162 | 85/F | Small B-cell lymphoma with aggressive genetic features | Morphologic and immunophenotypic features consistent with small B-cell lymphoma in a patient with an aggressive clinical course. Complex karyotype including IGH::ETV6 rearrangement, high mutational burden. |
| 250 | 89/M | Composite lymphoma, CLL/SLL, and mantle cell lymphoma | Patient with a prior diagnosis of stable untreated CLL/SLL presenting with progressive lymphocytosis, anemia, and thrombocytopenia. Development of second, clonally unrelated lymphoma, mantle cell lymphoma with leukemic presentation. |
| 258 | 76/M | Therapy-related acute leukemia | Morphologic features consistent with acute leukemia, likely therapy related. Additional immunophenotyping recommended to confirm immunophenotype. |
ALCL, anaplastic large cell lymphoma; CLL/SLL, chronic lymphocytic leukemia/small lymphocytic lymphoma; EBV, Epstein-Barr virus; NK, natural killer.