TOPKAT (toxicity prediction) analysis of compounds (1–10) isolated from the ethyl acetate extract of Aspergillus sp. obtained from the soft coral Sinularia species^a.

Compounds	Ames prediction	Rat oral LD50	Rat chronic LOAEL	Skin irritancy	Ocular irritancy	Rat female NTP	Rat male NTP
1	Non-mutagen	0.16	0.0038	Mild	None	Non-carcinogen	Carcinogen
2	Non-mutagen	0.29	0.0033	Mild	None	Non-carcinogen	Carcinogen
3	Non-mutagen	1.14	0.0043	Mild	Mild	Non-carcinogen	Non-carcinogen
4	Non-mutagen	1.43	0.0026	Mild	Mild	Non-carcinogen	Non-carcinogen
5	Non-mutagen	1.34	0.0036	Mild	Mild	Non-carcinogen	Non-carcinogen
6	Non-mutagen	0.82	0.0145	None	Moderate	Non-carcinogen	Carcinogen
7	Non-mutagen	0.89	0.0076	Mild	Moderate	Non-carcinogen	Carcinogen
8	Non-mutagen	0.56	0.0218	None	Moderate	Non-carcinogen	Carcinogen
9	Non-mutagen	9.68	0.9891	Mild	None	Carcinogen	Non-carcinogen
10	Non-mutagen	4.05	1.6549	None	Moderate	Carcinogen	Non-carcinogen

^aBoth rat oral LD5 and rat chronic LOAEL are expressed in g kg⁻¹-body-weight.