Figure 1. Translocator Protein Total Distribution Volume (TSPO VT) in Brain Regions of Interest in Persons With COVID-19 Disease and Depression With or Without Other Cognitive Symptoms (COVID-DC) vs Healthy Persons.
Closed triangles represent high-affinity binders; open triangles, mixed-affinity binders (MAB); dark blue symbols, 20 persons with COVID-DC; light blue symbols, 20 healthy persons; horizontal orange lines, group means. After correcting for genotype effect by multiplying MAB TSPO VT by a factor of 1.4, nonparametric comparison with the Mann-Whitney U test yielded similar levels of statistical significance (ventral striatum, U = 117, P = .02; dorsal putamen, U = 121, P = .03; hippocampus, U = 156, P = .24; prefrontal cortex, U = 164, P = .34; anterior cingulate cortex, U = 143, P = .13).