Lower baseline LDL‐C ≤107 mg/dL
Combinations of QI strategies (no. of arms)		Post‐intervention meana LDL‐C mg/dL (95% CrI)b	Absolute mean differencecLDL‐C mg/dL (95% CrI)
Five most common combinations of QI strategies observed in included studies reporting LDL‐C
CM + PE + PSM (n = 16)		90.63 (88.85 to 92.41)	‐3.84 (‐5.77 to ‐1.87)
CM + TC + PE + PSM (n = 7)		88.38 (86.55 to 90.22)	‐6.08 (‐8.07 to ‐4.11)
CM + EPR + PE + PSM (n = 5)		90.85 (88.44 to 93.26)	‐3.61 (‐6.21 to ‐1.00)
CM + FR + PE + PSM (n = 4)		89.41 (87.16 to 91.66)	‐5.05 (‐7.52 to ‐2.60)
CM + TC + PE (n = 4)		88.73 (86.63 to 90.82)	‐5.73 (‐7.93 to ‐3.61)
Sequential combination of the model‐estimated five most effective QI strategies for LDL‐C
TC + PE		90.33 (88.05 to 92.61)	‐4.13 (‐6.38 to ‐1.93)
TC + PE + CM		88.73 (86.63 to 90.82)	‐5.73 (‐7.93 to ‐3.61)
TC + PE + CM + FR		87.52 (84.94 to 90.05)	‐6.94 (‐9.69 to ‐4.33)
TC + PE + CM + FR + PSM		87.17 (84.90 to 89.39)	‐7.29 (‐9.76 to ‐4.91)
Higher baseline LDL‐C > 107 mg/dL
Combinations of QI strategies (no. of arms)	Post‐intervention meana LDL‐C mg/dL (95% CrI)d		Absolute mean differencecLDL‐C mg/dL (95% CrI)
Five most common combinations of QI strategies observed in included studies reporting LDL‐C
CM + TC + PE + PSM (n = 10)		105.40 (103.02 to 107.76)	‐3.07 (‐5.69 to ‐0.51)
CM + PE (n = 8)		108.23 (105.64 to 110.85)	‐0.25 (‐2.83 to 2.39)
CM + PE + PSM (n = 7)		108.47 (105.99 to 110.93)	‐0.02 (‐2.61 to 2.60)
TC + PE + PSM (n = 4)		107.47 (104.74 to 110.21)	‐1.00 (‐3.92 to 1.91)
CM + PE + PSM + PR (n = 4)		109.49 (106.23 to 112.74)	1.00 (‐2.31 to 4.33)
Sequential combination of the model‐estimated five most effective QI strategies for LDL‐C
TC + CM		103.33 (100.69 to 105.98)	‐5.15 (‐7.59 to ‐2.70)
TC + CM + CR		102.96 (99.16 to 106.70)	‐5.52 (‐9.24 to ‐1.89)
TC + CM + CR + CE		102.46 (98.09 to 107.01)	‐6.01 (‐10.38 to ‐1.54)
TC + CM + CR + CE + FR		102.82 (97.97 to 107.68)	‐5.65 (‐10.51 to ‐0.81)