Table 2.
Mutation rate and mean codon similarity of QS proteins in P. aeruginosa . We used GAMMA to query QS genes against 852 isolates. We used PAK as a reference for RhlI and PqsD, U0330A as a reference for MexT and PAO1 as a reference for all other genes. GAMMA assigns isolates with a codon similarity measure, which reflects the type of amino acid change or truncation. A low score reflects a likely change in function of the protein, and a score of 1 reflects the isolate is identical to the reference. We found that LasR had the lowest mean codon similarity and RsaL the highest
|
Gene |
Total |
Mutant |
Percent mutant |
Codon similarity |
|---|---|---|---|---|
|
LasR |
826 |
425 |
51.45 % |
0.9343 |
|
MucA |
850 |
257 |
30.24 % |
0.9450 |
|
MexT |
847 |
719 |
84.89 % |
0.9687 |
|
RhlR |
850 |
104 |
12.24 % |
0.9925 |
|
PqsA |
826 |
302 |
36.56 % |
0.9945 |
|
LasI |
832 |
33 |
3.97 % |
0.9949 |
|
PqsE |
844 |
101 |
11.97 % |
0.9951 |
|
PqsD |
847 |
240 |
28.34 % |
0.9953 |
|
PqsL |
850 |
447 |
52.59 % |
0.9953 |
|
VqsR |
849 |
256 |
30.15 % |
0.9955 |
|
QscR |
848 |
101 |
11.91 % |
0.9967 |
|
PqsR |
852 |
200 |
23.47 % |
0.9970 |
|
RhlI |
850 |
198 |
23.29 % |
0.9981 |
|
PqsB |
847 |
260 |
30.70 % |
0.9984 |
|
PqsH |
848 |
336 |
39.62 % |
0.9986 |
|
PsdR |
844 |
38 |
4.50 % |
0.9990 |
|
PqsC |
847 |
164 |
19.36 % |
0.9993 |
|
RpsL |
852 |
21 |
2.46 % |
0.9998 |
|
RsaL |
830 |
6 |
0.72 % |
0.9999 |