Table 4.
MSCs and their effect on SCI
| Invasive procedure | Passage continuity | Proliferation | Neural differentiation capacity | Anti-inflammatory effect on SCI | Glial scar reduction | Immuno-modulatory activity | Secretome | Related research | |
|---|---|---|---|---|---|---|---|---|---|
| Bone marrow MSCs | +++ | + | + | ++ | ++ | ++ | +++ | Mainly angiogenic factors | +++ |
| Umbilical cord MSCs | – | +++ | +++ | +++ | +++ | ++ | ++ | Mainly neurotrophic factors | ++ |
| Adipose MSCs | + | ++ | ++ | + | ++ | ++ | ++ | Mainly angiogenic factors | + |
* –: None; +: mild degree; ++: moderate degree; +++: severe degree. MSCs: Mesenchymal stem cells; SCI: spinal cord injury.