Figure 1. EWS RBD binds to the SON-GGU RNA stem-loop.
A) Predicted secondary structure of the SON-GGU oligonucleotide using the RNAfold web server 46. Nucleotides are color-coded according to their likelihood of forming base pairs. EMSA of 2.5 μM SON-GGU RNA stem-loop titrated with 8 nM – 80 μM of (B)EWSRRM, (C) EWSRG2, (D) EWSRRM-RG2 or (E) EWSRRM-RG2-ZnF.