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Effect of conjugates 3, 15, and 21 on ROS production in PC3 and HaCaT cells. Cells were incubated with tested compounds at their IC50 concentration for 2 and 12 h. Fluorescence intensity (FI) of the probe was measured by DCF (1 μM). The results are expressed as mean ± SD of three experiments, each of them performed in triplicate. ***p ≤ 0.0001, **p ≤ 0.001, and *p ≤ 0.01, as compared to the control.
