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. 2023 May 18;8(21):18663–18684. doi: 10.1021/acsomega.3c00554

Figure 5.

Figure 5

Electrophoretic analysis of S. aureus topoisomerase IV decatenation assay showing catenated kDNA and the decatenated mini circles (D) and the effect of tested compounds on topoisomerase IV activity. Decreasing amounts of compounds were incubated with 200 ng of kinetoplast DNA and run on agarose gel. Lane 1: S. aureus topoisomerase IV assay with dilution buffer (control, C). Lanes 2–6: compound 5 at concentrations 64, 32, 8, 2, and 0.5 μg/mL, respectively. Lanes 7–10: MFX at concentrations 5, 2.5, 1, and 0.1 μg/mL, respectively.