Table 2. Activity of Compounds 1–21 against Clinical Bacterial Strains— MICs (μg/mL).
| compound | S. aureus 180 | S. aureus 5595 | S. aureus T5595 | S. aureus T5591 | S. epidermidis 4341 | S. epidermidis 5253 | S. epidermidis KR4243/1 | S. pasteuri KR 4358 | P. aeruginosa 37 | P. aeruginosa 659 | E. coli 951 | E. coli 520 | E. coli 600 | E. cloacae 8 | K. pneumoniae 28 | K. pneumoniae 510 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 0.8 | 0.8 | 0.4 | 0.8 | >25.6 | >25.6 | 0.4 | 0.4 | >25.6 | >25.6 | >25.6 | 1.6 | >25.6 | 3.2 | >25.6 | >25.6 |
| 2 | 0.4 | 0.4 | 0.2 | 0.2 | 12.8 | 25.6 | 0.2 | 0.2 | 12.8 | 6.4 | 6.4 | 0.2 | 0.2 | 0.05 | >25.6 | 25.6 |
| 3 | 0.4 | 0.4 | 0.2 | 0.1 | 12.8 | >25.6 | 0.2 | 0.2 | >25.6 | >25.6 | >25.6 | 0.4 | 0.4 | 0.8 | >25.6 | 25.6 |
| 4 | 0.2 | 0.2 | 0.4 | 0.4 | 6.4 | 25.6 | 0.2 | 0.2 | >25.6 | >25.6 | 25.6 | 0.8 | 0.8 | 0.8 | >25.6 | >25.6 |
| 5 | 0.4 | 0.4 | 0.4 | 0.4 | 12.8 | >25.6 | 0.2 | 0.2 | 0.8 | 0.8 | 0.8 | 0.025 | 0.025 | 0.05 | >25.6 | 6.4 |
| 6 | 0.1 | 0.1 | 0.2 | 0.2 | 6.4 | 12.8 | 0.2 | 0.2 | 6.4 | 12.8 | 12.8 | 0.4 | 0.4 | 0.8 | >25.6 | >25.6 |
| 7 | 0.5 | 0.5 | 0.4 | 0.4 | 25.6 | >25.6 | 0.2 | 0.2 | >25.6 | >25.6 | >25.6 | 6.4 | 6.4 | 16 | >25.6 | >25.6 |
| 8 | 0.8 | 0.4 | 0.8 | 1.6 | 12.8 | 25.6 | 0.4 | 0.2 | 12.8 | 6.4 | 6.4 | 0.2 | 0.2 | 0.8 | >25.6 | 25.6 |
| 9 | 0.5 | 0.5 | 0.2 | 0.1 | 16 | 128 | 0.1 | 0.2 | 128 | >25.6 | 64 | 0.8 | –0.4 | 2 | >25.6 | >25.6 |
| 10 | 0.8 | 0.8 | 0.8 | 0.8 | 25.6 | >25.6 | 0.4 | 0.2 | 0.8 | 0.8 | 0.4 | 0.1 | 0.05 | 0.05 | >25.6 | 6.4 |
| 11 | 0.8 | 0.8 | 0.8 | 0.8 | 25.6 | >25.6 | 0.4 | 0.2 | 0.8 | 0.8 | 0.4 | 0.1 | 0.05 | 0.05 | >25.6 | 6.4 |
| 12 | 0.5 | 0.5 | 0.8 | 0.8 | 64 | >25.6 | 0.8 | 0.8 | >25.6 | >25.6 | >25.6 | 0.8 | 0.4 | >25.6 | >25.6 | >25.6 |
| 13 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 |
| 14 | 0.5 | 0.5 | 0.2 | 0.2 | >25.6 | >25.6 | 0.1 | 0.2 | >25.6 | >25.6 | >25.6 | 0.4 | 0.8 | 2 | >25.6 | >25.6 |
| 15 | 0.5 | 0.5 | 0.4 | 0.4 | >25.6 | >25.6 | 0.2 | 0.2 | >25.6 | >25.6 | >25.6 | 3.2 | 3.2 | >25.6 | >25.6 | >25.6 |
| 16 | 1 | 1 | 0.4 | 0.4 | 25.6 | >25.6 | 0.4 | 0.4 | >25.6 | >25.6 | >25.6 | 3.2 | 6.4 | 8 | >25.6 | >25.6 |
| 17 | 1.6 | 0.4 | 0.8 | 1.6 | 25.6 | 25.6 | 0.2 | 1.6 | >25.6 | >25.6 | >25.6 | 3.2 | 12.8 | 25.6 | >25.6 | >25.6 |
| 18 | 6.4 | 6.4 | 6.4 | 6.4 | >25.6 | >25.6 | 3.2 | 3.2 | 12.8 | >25.6 | 6.4 | 1.6 | 0.4 | 0.8 | >25.6 | >25.6 |
| 19 | 1.6 | 0.8 | 1.6 | 0.8 | >25.6 | >25.6 | 1.6 | 1.6 | >25.6 | 25.6 | 25.6 | 3.2 | 3.2 | 3.2 | >25.6 | >25.6 |
| 20 | 1 | 1 | 0.8 | 0.8 | >25.6 | >25.6 | 0.8 | 0.8 | >25.6 | >25.6 | >25.6 | 12.8 | 12.8 | >25.6 | >25.6 | >25.6 |
| 21 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 | >25.6 |
| CP | 0.5 | 0.5 | 0.25 | 0.25 | 16 | >25.6 | 0.25 | 0.13 | 1 | 0.5 | 0.5 | 0.06 | 0.03 | 0.06 | >25.6 | 4 |