Table 1. Effect of Different Amounts of Catalyst, Temperature, and Solvent on the Synthesis of Fused Nicotinonitrile Derivatives.

entry	solvent	time (min)	cat. (mg)	temp. (°C)	yield (%)
1		50	20	110	85
2		80	10	110	70
3		120	5	110	30
4		65	15	110	45
5		60	30	110	82
6		180		110	15
7		180	20	25
8		120	20	50	25
9		100	20	80	42
10		65	20	100	72
11		50	20	120	80
12	n-hexane	180	20	reflux
13	EtOH	120	20	reflux	72
14	MeOH	120	20	reflux	65
15	DMF	100	20	110	70
16	CH2Cl2	180	20	reflux
17	CHCl3	180	20	reflux
18	CH3CN	120	20	reflux	42
19	EtOAc	180	20	reflux
20	H2O	120	20	reflux	27