Table 1. In Vitro Cytotoxicity of Eugenol Derivatives (5–17)a.
| half
maximal inhibitory concentration (IC50, μM) |
|||
|---|---|---|---|
| compounds | breast MCF7 | ovarian SKOV3 | prostate PC3 |
| 5 | 25.74 ± 3.52 | 15.73 ± 3.43 | 11.18 ± 2.72 |
| 6 | 16.33 ± 2.80 | 41.06 ± 5.27 | 16.98± 1.08 |
| 7 | 45.89 ± 3.80 | 65.4 ± 2.81 | 24.30 ± 1.53 |
| 8 | 10.74 ± 2.76 | 70.01 ± 2.42 | 29.96 ± 0.91 |
| 9 | 2.87±0.56 | 3.36±0.80 | 2.09±0.68 |
| 10 | 45.01 ± 2.92 | 8.74 ± 1.06 | 7.07 ± 3.90 |
| 11 | 15.21 ± 3.77 | 26.33 ± 3.09 | 51.09 ± 2.92 |
| 12 | 6.54 ± 1.42 | 14.09 ± 2.17 | 16.72 ± 4.10 |
| 13 | 38.92 ± 3.20 | 61.09 ± 3.84 | 20.27 ± 0.75 |
| 14 | 172.86 ± 1.36 | 181.46 ± 3.58 | 124.90 ± 0.36 |
| 15 | 9.55 ± 0.71 | 16.86 ± 1.64 | 10.01 ± 0.99 |
| 16 | 33.18 ± 2.04 | 19.54 ± 2.48 | 26.65 ± 0.86 |
| 17 | 1.71±0.95 | 1.84±0.27 | 1.1±0.07 |
| doxorubicin | 1.74 ± 0.34 | 2.88 ± 0.68 | 2.61 ± 0.23 |
Data represent the mean values ± standard deviation of three independent experiments.