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. 2023 May 15;8(21):18811–18822. doi: 10.1021/acsomega.3c00933

Table 1. In Vitro Cytotoxicity of Eugenol Derivatives (5–17)a.

  half maximal inhibitory concentration (IC50, μM)
compounds breast MCF7 ovarian SKOV3 prostate PC3
5 25.74 ± 3.52 15.73 ± 3.43 11.18 ± 2.72
6 16.33 ± 2.80 41.06 ± 5.27 16.98± 1.08
7 45.89 ± 3.80 65.4 ± 2.81 24.30 ± 1.53
8 10.74 ± 2.76 70.01 ± 2.42 29.96 ± 0.91
9 2.87±0.56 3.36±0.80 2.09±0.68
10 45.01 ± 2.92 8.74 ± 1.06 7.07 ± 3.90
11 15.21 ± 3.77 26.33 ± 3.09 51.09 ± 2.92
12 6.54 ± 1.42 14.09 ± 2.17 16.72 ± 4.10
13 38.92 ± 3.20 61.09 ± 3.84 20.27 ± 0.75
14 172.86 ± 1.36 181.46 ± 3.58 124.90 ± 0.36
15 9.55 ± 0.71 16.86 ± 1.64 10.01 ± 0.99
16 33.18 ± 2.04 19.54 ± 2.48 26.65 ± 0.86
17 1.71±0.95 1.84±0.27 1.1±0.07
doxorubicin 1.74 ± 0.34 2.88 ± 0.68 2.61 ± 0.23
a

Data represent the mean values ± standard deviation of three independent experiments.