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. 2023 May 31;20:134. doi: 10.1186/s12974-023-02774-1

Fig. 2.

Fig. 2

Transcriptomic differences in forebrain samples of Csf1r+/+ or Csf1r+/− male mice. A Heatmap showing differentially expressed genes (DEGs) in 9-month-old cerebral brains from four Csf1r+/+ or Csf1r+/− mice. The color key (from blue to red) of the Z-score value (− 1.44–2.25) indicates low to high expression levels. B. KEGG pathway analysis of DEGs showing enrichment for the phagosome-related pathways in the cortices of Csf1r+/− mice. The top ten high confidence pathways and phagocytosis-associated pathways (red). C, D GSEA of DEGs in forebrain samples of Csf1r+/+ or Csf1r+/− mice showing enrichment with upregulated gene sets in the phagosome pathway in CSF1R haploinsufficient mice (C) and enrichment with downregulated gene sets in the Toll-like receptor signal pathway (D)