Fig. 5.

Minocycline partially improves behavioral defects in Csf1r^+/− mice. A Schematic timeline of the minocycline treatment timeline. Eight-month-old Csf1r^+/+ or Csf1r^+/− mice were intraperitoneally (i.p.) administrated with 50 mg/kg minocycline or saline for one month, followed by behavioral and pathological analyses. B Percentage of alternation triplet time within 5 min in the T-maze test following minocycline administration (n = 13–26 mice). C Time spent in the white box in light–dark transition test following minocycline administration (n = 13–26 mice). Data are presented as means ± SEM. P-values were calculated using Two-way ANOVA post-Sidak’s multiple comparisons tests. *p < 0.05, ***p < 0.001, ****p < 0.0001. Mino, minocycline