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. 2023 May 31;20:134. doi: 10.1186/s12974-023-02774-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Minocycline partially restores synaptic density in forebrain tissue of Csf1r^+/− mice. A Electron micrographs of synapse density in the CA1 area of forebrain sections from 9-month-old Csf1r^+/+ or Csf1r^+/− mice administered or not minocycline. B The number of synapses in the CA1 area of Csf1r^+/+ or Csf1r^+/− mice treated or not with minocycline was analyzed (n = 4 mice per group). C Western blot detection of postsynaptic membrane protein marker (PSD95) and presynaptic membrane protein marker (VGLUT1) in forebrain lysates of Csf1r^+/+ or Csf1r^+/− mice treated or not with minocycline. D PSD95 protein levels quantified by densitometry with GAPDH for comparison (n = 5 mice per group). E VGLUT1 protein levels quantified by densitometry with GAPDH for comparison (n = 5 mice per group). Data are presented as means ± SEM. P-values were calculated using two-way ANOVA post-Sidak’s multiple comparisons tests. **p < 0.01, ***p < 0.001, ****p < 0.0001, ns, no significance. Mino, minocycline