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Schematic of the mechanism of minocycline action alleviating ALSP pathology in Csf1r+/− mice. Csf1r haploinsufficiency results in the dyshomeostasis of microglia, including an enhanced inflammatory and myelin-phagocytic phenotype, a primary cause of ALSP pathogenesis. Minocycline significantly improves ALSP pathogenesis through inhibition of inflammation and myelin phagocytosis by microglia
