Figure 4.

Seeded Aβ in mice receiving the dispersible fraction from p-preAD case 14. (A) Seeded plaques stained with a non-C terminus-specific polyclonal antibody raised against Aβ₁₋₄₀. The Aβ deposits were easily detectable even at low magnification level. (B and C) At low magnification level Aβ_N3pE- and Aβ_pSer8-positive plaques were less widespread and less visible. Calibration bar in C is valid for A–C. (D and E) At high power magnification both Aβ_N3pE and Aβ_pSer8 was seen at the white matter next to the hippocampal sector CA1. Note that Aβ_N3pE-positive material was more widely distributed compared to Aβ_pSer8. Calibration bar in E is valid for D and E.