Figure 5.

Schematic representation of Aβ protein deposition, propagation, maturation and its acceleration by seeds. Although Aβ propagation and maturation correlate with one another³⁰ acceleration of these two aspects in the pathogenesis of Alzheimer’s disease is modified in a differential manner: propagation of Aβ deposition is accelerated by any kind of Aβ seeds whereas maturation increase depends on the presence of Aβ_N3pE and Aβ_pSer8 in the seeds in a biochemically detectable concentration. Note that Aβ_pSer8-positive plaques are mainly cored plaques.