Table 1.
Prevalence of plaques exhibiting Aβ (detected with antibodies against non-modified Aβ), AβN3pE and AβpSer8 in the human brain
| Brain region | Antibody | Aβ phase 0 (n = 9) | Aβ phase 1 (n = 6) | Aβ phase 2 (n = 8) | Aβ phase 3 (n = 7) | Aβ phase 4 (n = 3) | Aβ phase 5 (n = 11) |
|---|---|---|---|---|---|---|---|
| Temporal neocortex | Aβ | 0.00 | 83.33 | 100.00 | 100.00 | 100.00 | 100.00 |
| AβN3PE | 0.00 | 66.67 | 87.50 | 87.50 | 100.00 | 100.00 | |
| AβpSer8 | 0.00 | 0.00 | 25.00 | 57.10 | 100.00 | 90.90 | |
| Cingulate gyrus | Aβ | 0.00 | 0.00 | 62.50 | 100.00 | 100.00 | 100.00 |
| AβN3PE | 0.00 | 0.00 | 50.00 | 100.00 | 100.00 | 100.00 | |
| AβpSer8 | 0.00 | 0.00 | 12.50 | 57.10 | 100.00 | 54.50 | |
| Putamen | Aβ | 0.00 | 0.00 | 0.00 | 100.00 | 100.00 | 100.00 |
| AβN3PE | 0.00 | 0.00 | 0.00 | 87.50 | 66.67 | 100.00 | |
| AβpSer8 | 0.00 | 0.00 | 0.00 | 0.00 | 33.33 | 36.40 | |
| Cerebellar cortex | Aβ | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 90.90 |
| AβN3PE | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 90.90 | |
| AβpSer8 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 9.10 |
Percentages of cases in each Aβ phase exhibiting the respectively stained plaques in the human brain in the temporal neocortex (Brodmann area 36), cingulate gyrus (Brodmann area 24), putamen and cerebellar cortex are provided (n = 44 cases). A single Aβ phase 1 case exhibited plaques only in the occipital neocortex but not in the temporal cortex. Few Aβ phase 2 cases showed plaques in the entorhinal cortex/hippocampus while none were seen in the cingulate gyrus. One Aβ phase 5 case with Aβ plaques in the pons had no cerebellar plaques. Values in bold highlight positive percentage >76%.