Table 8.
ADME properties of compounds 5f and 5 g.
| Compd. | GI Abs. | BBB | P-gp substrate | CYP1A2 inhibitor | CYP2C19 inhibitor | CYP2C9 inhibitor | CYP2D6 inhibitor | CYP3A4 inhibitor |
|---|---|---|---|---|---|---|---|---|
| 5f | High | Yes | Yes | No | Yes | Yes | Yes | Yes |
| 5g | High | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
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