Table 1.
Inclusion of the basic features of the study.
| study | country | definite diagnosis | number(intervention/control) | age(intervention/control,y) | female(intervention/control,%) | BMI(intervention/control,kg/m2) | Probiotic components | intervention time |
|---|---|---|---|---|---|---|---|---|
| Ferolla SM,2016 | Brazil | hepatic biopsy | 26/23 | 57.3(25–74) | 38(76) | 32.5 ± 4.0/32.5 ± 4.0 | lactobacillus | 12 weeks |
| Bakhshimoghaddam F,2018 | Iran | ultrasonic examination | 34/34 | 38.8 ± 9.0/41.1 ± 8.5 | 17(50)/17(50) | 30.5 ± 4.6/31.9 ± 5.1 | bifidobacterium, lactobacillus | 24 weeks |
| Ekhlasi G,2016 | Iran | ultrasonic examination | 15/15 | 25–64 | NR | 27.28 ± 2.21/27.84 ± 1.96 | lactobacillus, bifidobacterium, streptococcus | 8 weeks |
| Sepideh A,2015 | Iran | ultrasonic examination | 21/21 | 42.10 ± 1.99/47.33 ± 2.53 | 8(38.1)/6(28.6) | 30.34 ± 1.17/29.50 ± 0.84 | lactobacillus, bifidobacterium, streptococcus | 8 weeks |
| Behrouz V,2017 | Iran | ultrasonic examination | 30/30 | 38.46 ± 7.11/38.43 ± 10.09 | 8(26.7)/9(30) | 29.56 ± 2.54/31.90 ± 5.04 | lactobacillus, bifidobacterium | 12 weeks |
| Famouri F,2017 | Iran | ultrasonic examination | 32/32 | 12.7 ± 2.2/12.6 ± 1.7 | 18(56.2)/14(43.8) | 26.44 ± 4.3/26.61 ± 2.26 | lactobacillus, bifidobacterium | 12 weeks |
| Duseja A,2019 | India | hepatic biopsy | 19/20 | 38 ± 10/33 ± 6 | 6(32)/5(25) | 26 ± 3/27 ± 4 | lactobacillus, bifidobacterium | 12 months |
| Abdel Monem SM,2017 | Egypt | hepatic biopsy | 15/15 | 44.20 ± 5.51/44.33 ± 5.62 | 6(40)/7(46.7) | 32.56 ± 1.19/33.05 ± 1.27 | lactobacillus | 1 months |
| Cai GS,2020 | China | ultrasonic examination | 70/70 | 46.13 ± 12.72/49.62 ± 9.08 | 24(34.29)/31(44.29) | 31.28 ± 3.62/30.73 ± 3.47 | lactobacillus, bifidobacterium, enterococcus | 3 months |
| Alisi A,2014 | Italy | ultrasonic examination | 22/22 | 11(10–12)/10(9–12) | 8(36.36)/12(54.55) | 25.6(23.2–27.9)/27.3(24.7–28.6) | lactobacillus, bifidobacterium, streptococcus | 16 weeks |
| Mofidi F,2017 | Iran | ultrasonic examination | 21/21 | 40.09 ± 11.44/44.61 ± 10.12 | 10(47.62)/9(42.86) | 23.17 ± 1.01/23.20 ± 1.07 | lactobacillus, bifidobacterium, streptococcus | 28 weeks |
| Eslamparast T,2014 | Iran | ultrasonic examination | 26/26 | 46.35 ± 8.8/45.69 ± 9.5 | 12(46.15)/15(57.69) | 32.1 ± 2.4/31.3 ± 2.3 | lactobacillus, bifidobacterium, streptococcus | 28 weeks |
| Jiang Yanyan,2020 | China | ultrasonic examination | 36/36 | 51.84 ± 10.46/51.56 ± 14.83 | 14(38.89)/16(44.44) | NR | bifidobacterium | 12 weeks |
| Wang Lingjuan,2019 | China | ultrasonic examination | 60/60 | 6–14 | NR | NR | bifidobacterium | 3 months |
| Shavakhi A,2013 | Iran | hepatic biopsy | 32/31 | 41.5 ± 12.7/38.7 ± 11.9 | 17(53.13)/14(45.16) | 28.6 ± 2/28.2 ± 2.5 | lactobacillus, bifidobacterium, streptococcus | 6 months |
| Nabavi S,2014 | Iran | ultrasonic examination | 36/36 | 42.75 ± 8.72/44.05 ± 8.14 | 19(52.8)/18(50) | 30.1 ± 3.61/31.4 ± 3.6 | lactobacillus, bifidobacterium | 8 weeks |
| Asgharian A,2016 | Iran | ultrasonic examination | 38/36 | 46.57 ± 1.7/47.78 ± 1.7 | 33(82.5)/22(64.7) | 29.58 ± 0.76/28.18 ± 0.68 | lactobacillus, bifidobacterium, streptococcus | 8 weeks |
| Manzhalii E,2017 | Ukraine | ultrasonic examination | 38/37 | 44.3 ± 1.5/43.5 ± 1.3 | 27(71.05)/21(56.76) | 26.4 ± 0.8/26.6 ± 0.7 | lactobacillus, bifidobacterium, streptococcus | 12 weeks |