. 2023 Jun 1;56(2):301–314. doi: 10.1007/s11239-023-02834-6

Table 2.

Tools for thrombosis prediction used in clinical practice

Scales used for thrombosis risk assessment
-Includes five clotting assays and six enzyme-linked immunosorbent assays: -anti-CL (IgG and IgM) -anti-β2GPI (IgG and IgM), -aPS/PT (IgG and IgM) -Enables the calculation of relative risks using OR to approximate the results for each antibody -The upper limit for each APLAs is 20 -APL-S score ≥ 30 is an independent risk factor for thrombosis [70]	-Scored based on calculations using multivariate logistic regression analysis -It includes six independent risk factors for thrombosis or pregnancy loss – hyperlipidemia, hypertension, LA, anti-CL (IgG and IgM), anti-β2GPI (IgG and IgM, and aPS/PT (IgG and IgM) -Points are given for variables proportionally to their regression coefficient [69]	-The scale includes the same criteria as GAPSS except for aPS/PT in class IgG and IgM (aPS/PT are not routinely tested) [71]

Scales used for thrombosis risk assessment

APL-S

GAPSS

aGAPSS

Antiphospholipid score

Global APS Score

Adjusted Global APS Score

-Includes five clotting assays and six enzyme-linked immunosorbent assays:

-anti-CL (IgG and IgM)

-anti-β2GPI (IgG and IgM),

-aPS/PT (IgG and IgM)

-Enables the calculation of relative risks using OR to approximate the results for each antibody

-The upper limit for each APLAs is 20

-APL-S score ≥ 30 is an independent risk factor for thrombosis [70]

-Scored based on calculations using multivariate logistic regression analysis

-It includes six independent risk factors for thrombosis or pregnancy loss – hyperlipidemia, hypertension, LA, anti-CL (IgG and IgM), anti-β2GPI (IgG and IgM, and aPS/PT (IgG and IgM)

-Points are given for variables proportionally to their regression coefficient [69]

-The scale includes the same criteria as GAPSS except for aPS/PT in class IgG and IgM

(aPS/PT are not routinely tested) [71]

APS antiphospholipid syndrom, OR odds ratio, aPS/PT phosphatidylserine-dependent antiprothrombin antibodies, anti-β2GPI anti-β2Glycoprotein-I antibodies, IgM immunoglobulin M, IgG immunoglobulin G, anti-CL anticardiolipin antibodies