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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: Clin Immunol. 2023 Apr 2;250:109317. doi: 10.1016/j.clim.2023.109317

Figure 2. Attenuation of nephritis in Ager−/− MRL-lpr mice at 18 weeks of age.

Figure 2.

(A) The transition of the urine albumin/Cr ratio (mg/gCr). Ager+/+ MRL-lpr (n = 7), and Ager−/− MRL-lpr (n = 7). aThe Mann‒Whitney U test for between-group comparisons; bWilcoxon signed-rank sum test for comparisons between 14 and 18 weeks. *P < 0.05. (B) Activity index. Ager+/+ MRL-lpr (n = 10), and Ager−/− MRL-lpr (n = 11). Student’s t-test. **P < 0.01. (C) Pathological findings of the kidney. Ager+/+ MRL-lpr shows cellular crescent (*) and karyorrhexis (arrowhead) of glomeruli (top: PAS staining). Moderate glomerular cell proliferation was found in Ager+/+ MRL-lpr mice (middle: PAS staining). By electron microscopy, subepithelial and subendothelial electron-dense deposits and podocyte foot process effacement were observed in Ager+/+ MRL-lpr mice (bottom). Representative images of Ager+/+ MRL-lpr (n = 10), and Ager−/− MRL-lpr (n = 11). NS, not significant, EM: electron microscopy; PAS, periodic acid-Schiff.