Table 4.

Dosages and adverse events and pharmacotherapies used in the management of DSPN in clinical practice (82–86).

Drug	Class of drug	Daily dosage range	Common side effects
Duloxetine	serotonin-norepinephrine reuptake inhibitors	30 – 120 mg	somnolence, headache, nausea, dry mouth
Amitriptyline	tricyclic antidepressants	10 – 100 mg	somnolence, dizziness, headache, dysarthria, aggression, dry mouth, nausea, constipation, weight gain, hyperhidrosis
Pregabalin	a2δ calcium channel ligand	75 – 600 mg	somnolence, dizziness, headache
Gabapentin	a2δ calcium channel ligand	300 – 3600 mg	somnolence, dizziness, ataxia,
Venlafaxine sustained release	serotonin-norepinephrine reuptake inhibitors	75 – 225 mg	insomnia, dizziness, sedation, headache, nausea, dry mouth, constipation, hyperhidrosis
Tapentadol extended release	µ-opioid	50 – 200 mg	somnolence, vertigo, headache, nausea, emesis
Oxycodone extended release	µ-opioid	10 – 50 mg	somnolence, vertigo, headache, nausea, constipation
Tramadol extended release	µ-opioid	50 – 200 mg	vertigo, nausea
Topical 8% Capsaicin patch	transient receptor potential vanilloid agonist	Plaster applied for 30 min every 60–90 days	pain and erythema in site of application