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Production of inflammatory mediators including IFN-γ, IFN-α, TGF-β, and NO can affect the metabolic profile of cardiac tissue, as can T. cruzi itself. Parasite mediators of cardiac metabolic modulation are still to be discovered. Created with BioRender.com. IFN-α, interferon-α; IFN-γ, interferon-γ; NO, nitric oxide; TCA, tricarboxylic acid; TGF-β, transforming growth factor-β.
