Table 2.
Final multivariable analysis of factors associated with donor lung acceptability in derivation cohort
| Parameter | β | Odds Ratio | 95% Confidence Interval | P-value | |
|---|---|---|---|---|---|
| Age (transformed) a | −0.00082 | -- | -- | -- | <.0001 |
| Maximum creatinine (transformed) a | 0.7133 | -- | -- | -- | <.0001 |
| PaO2/FiO2 ratio (transformed) a,b | 0.2501 | -- | -- | -- | <.0001 |
| Mechanism of death by asphyxiation/drowning (no vs.yes) | 0.2991 | 1.349 | 1.195 | 1.522 | <.0001 |
| Smoking history (>20 pack-years) (no vs. yes) | 0.9912 | 2.695 | 2.516 | 2.886 | <.0001 |
| Smoking history (>20 pack-years) (unknown vs. yes) | 0.6949 | 2.004 | 1.622 | 2.475 | <.0001 |
| History of MI (no vs. yes) | 0.3669 | 1.443 | 1.237 | 1.684 | <.0001 |
| History of MI (no vs. unknown) | −0.0393 | 0.961 | 0.718 | 1.288 | 0.7919 |
| Bloodstream infection (no vs. yes) | 0.2669 | 1.306 | 1.200 | 1.421 | <.0001 |
| Chest x-ray (normal vs. abnormal) c | 0.7046 | 2.023 | 1.921 | 2.130 | <.0001 |
| Cardiac Arrest (no vs. yes) d | 0.2478 | 1.281 | 1.162 | 1.413 | <.0001 |
Model intercept = −6.0705
a
Transformed age variable calculated as (age-20)2, transformed maximum creatinine variable calculated as (creatinine)−1/4, transformed PaO2/FiO2 ratio variable calculated as (PaO2/FiO2-200)1/2, with values less than 200 equal to 0.
b
To be determined within 2 hours prior to potential lung offer
c
To be determined within 3 hours prior to potential lung offer
d
Since neurological event that led to declaration of brain death
MI=myocardial infarction, PaO2/FiO2= ratio of arterial partial pressure of oxygen to fraction of inspired oxygen