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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: J Invest Dermatol. 2022 Apr 11;142(9):2363–2374.e18. doi: 10.1016/j.jid.2022.03.022

Figure 4. Th17/Th22 enrichment in skin correlates with clinical indices and with CD4+/CD8+ IL-22+ T-cell populations in the blood.

Figure 4.

Spearman correlation heat map of Th17-, Th22-, and IASI-S/IASI-E/IASI-SE in the skin and CD4+/CD8+ IL-22+ in the blood of patients with ichthyosis. The dendrogram represents the k-means clustering of marker/variables. +P < 0.1, ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. Cor, correlation; IASI-E, Ichthyosis Area Severity Index-Erythema; IASI-S, Ichthyosis Area Severity Index-Scaling; IASI-SE, Total Ichthyosis Area Severity Index; K, keratin; Th, T helper.