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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Br J Dermatol. 2022 Jul 4;187(4):557–570. doi: 10.1111/bjd.21687

Figure 5.

Figure 5

Mycobiome analysis for the control and ichthyosis groups. (a) Malassezia genus level alterations separated for ichthyosis subtypes. (b) Stacked bar charts of mycobiome highlighting only Malassezia spp. (P < 0·05) across the spectrum of ichthyosis subtypes. (c) Malassezia globosa and M. sympodialis were significantly reduced in all ichthyosis subtypes, whereas M. slooffiae was significantly increased in ichthyosis skin [except Netherton syndrome (NS)]. Malassezia restricta was significantly reduced in lamellar ichthyosis (LI) and NS subtypes. (d) Trichophyton at the genus level was augmented in all subtypes (except NS). (e) Stacked bar charts of mycobiome highlighting only Trichophyton spp. (P < 0·05) across the spectrum of ichthyosis subtypes. (f) Trichophyton unclassified species was significantly increased in all subtypes (except NS). Statistical significance was determined using permutation test on the Wilcoxon rank sum test statistic with multiple testing correction using familywise error rate as described in Appendix S1 (see Supporting Information) (*P < 0·05; **P < 0·01) was computed for (a), (c), (d) and (f). CIE, congenital ichthyosiform erythroderma; epidermolytic ichthyosis (EI); ns, not significant.