Table 4. Analysis of potential risk factors for NCI-CTCAE scores. According to the NCI-CTCAE scoring grade 0; no morbidity, grade 1 and 2; mild morbidity, grade 3, 4 and 5; severe morbidity.
| Variables | No morbidity (grade 0) n= 10 | Mild morbidity (grade 1-2) n= 28 | Severe morbidity (grade 3-4-5) n= 22 | p | Test statistic |
| Age, mean ± SE | 64.4 ± 3.77 | 60.89 ± 2.02 | 58.04 ± 3.30 | 0.423 | 0.8731 |
| Sex | |||||
| Male (n= 41) Female (n= 19) |
6 (14.64%) 4 (21.06%) |
20 (48.78%) 8 (42.10%) |
15 (36.58%) 7 (36.84%) |
0.800 | 0.4451 |
| Primary tumor origin | |||||
| Stomach (n= 33) | 7 (21.22%) | 16 (48.48%) | 10 (30.30%) | ||
| Colon (n= 21) | 2 (9.52%) | 8 (38.10%) | 11 (52.38%) | 0.240 | 7.9691 |
| Rectum (n= 5) | 1 (20%) | 4 (80%) | 0 | ||
| Appendix (n= 1) | 0 | 0 | 1 (100%) | ||
| Neoadjuvant therapy | |||||
| No (n= 50) | 7 (14%) | 24 (48%) | 19 (38%) | 0.463 | 1.5397 |
| Yes (n= 10) | 3 (30%) | 5 (50%) | 2 (20%) | ||
| Hypertension | |||||
| No (n= 31) | 3 (9.68%) | 16 (51.61%) | 12 (38.71%) | 0.318 | 2.2891 |
| Yes (n= 29) | 7 (24.15%) | 12 (41.37%) | 10 (34.48%) | ||
| Type II diabetes mellitus | |||||
| No (n= 47) | 7 (14.90%) | 23 (48.93%) | 17 (36.17%) | 0.718 | 0.6632 |
| Yes (n= 13) | 3 (23.08%) | 5 (38.46%) | 5 (38.46%) | ||
| Coronary artery disease | |||||
| No (n= 50) | 8 (16%) | 22 (44%) | 20 (40%) | 0.485 | 1.4462 |
| Yes (n= 10) | 2 (20%) | 6 (60%) | 2 (20%) | ||
| Cerebrovascular disease | |||||
| No (n= 58) | 10 (17.25%) | 27 (46.55%) | 21 (36.20%) | 0.798 | 0.4501 |
| Yes (n= 2) | 0 | 1 (50%) | 1 (50%) | ||
| Splenectomy | |||||
| No (n= 52) | 10 (19.23%) | 25 (48.07%) | 17 (32.70%) | 0.184 | 3.3847 |
| Yes (n= 8) | 0 | 3 (37.5%) | 5 (62.5%) | ||
| Enteric diversion | |||||
| No (n= 52) | 10 (19.23%) | 26 (50%) | 16 (30.77%) | 0.046 | 6.1663 |
| Yes (n= 8) | 0 | 2 (25%) | 6 (75%) | ||
| CC scores | |||||
| CC-0 (n= 37) | 7 (18.92%) | 19 (51.35) | 11 (29.73%) | ||
| CC-1 (n= 11) | 2 (18.18%) | 5 (45.46%) | 4 (36.36%) | 0.675 | 4.0119 |
| CC-2 (n= 6) | 0 | 2 (33.33%) | 4 (66.66%) | ||
| CC-3 (n= 6) | 1 (16.67%) | 2 (33.33%) | 3 (50%) | ||
| PCI, median (min-max) | 3.50 (0-39) | 4.00 (0-32) | 9.00 (0-39) | 0.185 | 3.3724 |
| PC | |||||
| Mild PC (n= 42) | 7 (16.66%) | 22 (52.38%) | 13 (30.96%) | 0.329 | 2.2263 |
| Severe PC (n= 18) | 3 (16.66%) | 6 (33.34%) | 9 (50%) | ||
| Surgery time (minute) Median (min-max) | 255 (225-375) | 300 (210-555) | 312 (115-495) | 0.166 | 3.5976 |
| Length of ICU stay (day) Median (min-max) | 0 (0-3) | 0 (0-3) | 1.5 (0-33) | 0.004 | 10.8360 |
| Length of hospital stay (day), Median (min-max) | 12 (10-14) | 14 (10-17) | 18.5 (10-47) | <0.001 | 17.4415 |
| CC: Complete cytoreduction, ICU: Intensive care unit, PC: Peritoneal carcinomatosis PCI: Peritoneal carcinomatosis index. | |||||