Table 1.
Results of PheWAS for PDE1A rs10171703
| Sources | Related traits | Stage | Cohort (reference no.) | Population | Covariates | Total N (case subjects) | RAF | β ± SE/OR (95% CI) | P |
|---|---|---|---|---|---|---|---|---|---|
| T2D Knowledge Portal | DBP | PheWAS | UK Biobank and ICBP BP GWAS (29) | Europeans | Sex, age, age2, BMI, and other study-specific covariates | 757,601 | 0.506 | 0.130 ± 0.017 | 4.1 × 10−14 |
| SBP | BP-related traits | UK Biobank and ICBP BP GWAS (29) | Europeans | Sex, age, age2, BMI, and other study-specific covariates | 738,170 | 0.505 | 0.098 ± 0.030 | 1.1 × 10−3 | |
| HT | BP-related traits | Heart rate and hypertension GWAS (with data from UK Biobank) (37) | Europeans | — | 458,554 (144,793) | 0.512 | 1.01(1.01–1.02) | 2.9 × 10−4 | |
| Body height | PheWAS | GIANT UK Biobank GWAS (38) | Europeans | Age, sex, recruitment center, genotyping batches, and PCs | 709,342 | 0.502 | −0.008 ± 0.001 | 4.2 × 10−9 | |
| PhenoScanner | TPM | PheWAS | UK Biobank (39,40) | Europeans | — | 330,995 | — | −0.009 ± 0.002 | 2.3 × 10−9 |
| PhenoScanner | TFM | PheWAS | UK Biobank (39,40) | Europeans | — | 331,030 | — | −0.009 ± 0.002 | 3.5 × 10−9 |
| Open Targets | ALM | PheWAS | UK Biobank (41) | Europeans | AFM, age, age2, PCs, assessment center, and genotyping array | 450,243 | 0.512 | −0.013 ± 0.002 | 1.2 × 10−11 |
ORs and 95% CIs were reported according to the CHD-related risk allele (C allele) of PDE1A rs10171703. AFM, apendicular fat mass; ALM, appendicular lean mass; GIANT, Genetic Investigation of ANthropometric Traits; HT, hypertension; RAF, risk allele frequency (C allele); TFM, trunk fat-free mass; TPM, trunk predicted mass.