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. 2023 May 15;8(6):1051–1063. doi: 10.1038/s41564-023-01389-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — (A) Representative micrograph of 4,907 used and 2D class averages for 05B04-hACE2 data collection. (B) Gold-standard FSC plot calculated in cryoSPARC for local refinement. (C) 3D classification and refinement logic tree for the 05B04-hACE2 cryo-EM data set. (D) Local resolution estimate for 05B04-hACE2 locally refined map and representative cryo-EM density contoured at 7σ for boxed regions. (E) Structural superposition of anti-hACE2 mAbs 05B04 (slate blue), 3E8 (orange), h11B11 (green) and SARS-CoV-2 RBD (gray) modeled on soluble ACE2 (wheat). (F, G) Comparison of anti-hACE2 mAb epitopes visualized on an ACE2 model (F) or highlighted on the ACE2 sequence (G). anti-hACE2 mAb epitopes are colored slate blue, orange, and green for 05B04, 3E8, and h11B11, respectively. The SARS-CoV-2 RBD epitope is denoted as shaded gray boxes (G).